Synthesis and monoamine transporter affinity of 3beta-(4-(2-pyrrolyl)phenyl)-8-azabicycl

Bioorg Med Chem Lett. 2001 Feb 26;11(4):487-9. doi: 10.1016/s0960-894x(00)00701-0.

Abstract

3Beta-(5-indolyl)-8-azabicyclo[3.2.1]octanes display potent binding affinity for both the dopamine and serotonin transporters, while certain 3beta-(4-(2-pyrrolyl)phenyl)-8-azabicyclo[3.2.1]octanes selectively bind to the serotonin transporter.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aza Compounds / chemical synthesis
  • Carrier Proteins / metabolism*
  • Dopamine Plasma Membrane Transport Proteins
  • Indoles / chemical synthesis
  • Membrane Glycoproteins / metabolism*
  • Membrane Transport Proteins*
  • Nerve Tissue Proteins*
  • Pyrroles / chemical synthesis
  • Serotonin Plasma Membrane Transport Proteins
  • Structure-Activity Relationship

Substances

  • Aza Compounds
  • Carrier Proteins
  • Dopamine Plasma Membrane Transport Proteins
  • Indoles
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • Pyrroles
  • Serotonin Plasma Membrane Transport Proteins